RAMIRO ARAYA MATURANA
 
 

Perfil

Nuestra línea de investigación está enfocada en la búsqueda de nuevas metodologías sintéticas para la obtención de moléculas bioactivas, especialmente en las áreas de compuestos anti cáncer y anti fúngicos. Además del estudio experimental y teórico de las moléculas obtenidas.

Formación Profesional

Químico/Lic. En Química Universidad de Chile,
Doctor en Ciencias Exactas mención Química P. Universidad Católica de Chile

Proyectos Vigentes

Como investigador principal:
2014-2017 “Synthesis and pharmacological evaluation of mitochondria-targeted antitumor quinones and hydroquinones” FONDECYT 1140753.

Como co-investigador:

  • 2015-2018 incorporation, distribution and dynamics of benzocaine, prilocaine and derivatives in the bilayer of a new membrane mimetic made of a natural phospholipids mixture.

  • 2013-2016 “Lipophilic cations of esters of alkyltriphenylphosphonium polyhydroxybenzoates as mitochondriotropic antineoplastic agents. antitumoral activity spectra on human tumour cells from different tissues” FONDECYT 1130772.

  • 2013-2016 “Integración de la Biología Estructural al desarrollo de la Bionanotecnología” ANILLO ACT 1107
  • Publicaciones Relevantes Últimos 5 Años

    • A Study about Regioisomeric Hydroquinones with Multiple Intramolecular Hydrogen Bonding, Martínez-Cifuentes M., Cardona W., Saitz C., Weiss-López B., Araya-Maturana R., Molecules, 2017, 22, 593-607.

    • Experimental and Theoretical Reduction Potentials of Some Biologically Active ortho-Carbonyl para-Quinones. Martínez-Cifuentes M., Salazar R., Ramírez-Rodríguez O., Weiss-López B., Araya-Maturana R. Molecules, 2017, 22, 577-586.

    • Protonation sites, tandem mass spectrometry and computational calculations of o-carbonyl carbazolequinone derivatives. Martínez -Cifuentes, M., Clavijo-Allancan, G., Zuñiga-Hormazabal, P., Aranda, B., Barriga, A., Weiss-López, B., Araya-Maturana, R. Int J Mol Sci, 17, 2016, Article number 1071.

    • Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation. Urra, F.A., Córdova-Delgado, M., Lapier, M., Orellana-Manzano, A., Acevedo-Arévalo, L., Pessoa-Mahana, H., González-Vivanco, J.M., Martínez-Cifuentes, M., Ramírez-Rodríguez, O., Millas-Vargas, J.P., Weiss-López, B., Pavani, M., Ferreira, J., Araya-Maturana, R. Toxicol Appl Pharm, 2016, 29146-57.

    • Correlating experimental electrochemistry and theoretical calculations in 2′-hydroxy chalcones: the role of the intramolecular hydrogen bond. Martínez-Cifuentes M., Salazar R.,. Escobar C. A, Weiss-López B. E., Santos L. S. Araya-Maturana R. RSC Adv. 2015, 50929-50937

    • Intramolecular Hydrogen Bond in Biologically Active o-Carbonyl Hydroquinones Martínez-Cifuentes M., Weiss-Lopez B. E., Santos L. S., Araya-Maturana R. Molecules, 2014, 9354-9368

    • On-Water Reactivity and Regioselectivity of Quinones in C–N Coupling with Amines: Experimental and Theoretical Study Martínez-Cifuentes M., Clavijo-Allancan G., Di Vaggio-Conejeros C., Weiss-López B., Araya-Maturana R. Aust J Chem, 2014, 217-224.

    • An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G(2)/M-phase arrest in mammary adenocarcinoma TA3 Urra, FA; Martinez-Cifuentes, M; Pavani, M; Lapier, M; Jana-Prado, F; Parra, E; Maya, JD; Pessoa-Mahana, H; Ferreira, J; Araya-Maturana, R. Toxicol Appl Pharm, 2013, 218-227

    • Mitochondria: A Promising Target For Anticancer Alkaloids Urra F A, Córdova-Delgado M., Pessoa-Mahana H., Ramírez-Rodríguez O., Weiss-López B., Ferreira J., Araya-Maturana R. Curr Top Med Chem, 2013, 2171-2183

    • Remote regio- and stereocontrol by the sulfinyl group: Diels-Alder reaction of sulfinyl dienols and 8,8-dimethylnaphthalene-1,4,5(8H)-trione Almodovar, I; Cardona, W; Delgado-Castro, T; Zapata-Torres, G; Rezende, MC; Araya-Maturana, R; Maestro, MC; Ruano, JLG. Tetrahedron-Asymmetr: 2013, 56-61

    Link ResearchGate