RAMIRO ARAYA MATURANA
 
 

Perfil

Nuestra línea de investigación está enfocada en la obtención eficiente de nuevas moléculas dirigidas a las mitocondrias, con actividad antitumoral y antiplaquetaria. Además del estudio experimental y teórico de su reactividad.

Formación Profesional

Químico/Lic. En Química Universidad de Chile,
Doctor en Ciencias Exactas mención Química P. Universidad Católica de Chile

Proyectos Vigentes

Como investigador principal:

  • 2018-2021 “New mitochondria-targeted anti-tumor compounds: Synthesis of anti-proliferative and anti-migratory phosphonium and pyridinium salts derived from acylpolyphenols” FONDECYT.
  • Como co-investigador:

  • 2018-2021 “Synthesis and Pharmacological Evaluation of Mitochondria-Targeted Hydroquinone Derivatives with Antiplatelet Activity” FONDECYT.

  • 2019-2022 “Incorporation mechanism of peptide TP1 into a membrane mimetic and into a model plasmatic membrane. 2H-NMR and Molecular Dynamics.” FONDECYT.
  • Publicaciones Relevantes Últimos 5 Años

    • Fuentes, E; Araya-Maturana, R; Urra Félix A. Regulation of mitochondrial function as a promising target in platelet activation-related diseases, Free Radical Biology and Medicine, 2019.

    • Martinez-Cifuentes, M; Monroy-Cardenas, M; Millas-Vargas, JP; Weiss-Lopez, BE; Araya-Maturana, R. Assessing Parameter Suitability for the Strength Evaluation of Intramolecular Resonance Assisted Hydrogen Bonding in o-Carbonyl Hydroquinones. MOLECULES, 2019, 24, artículo número 280.

    • Urra, FA; Muñoz, F; Cordova-Delgado, M; Ramirez, MP; Pena-Ahumada, B; Rios, M; Cruz, P; Ahumada-Castro, U; Bustos, G; Silva-Pavez, E; Pulgar, R; Morales, D; Varela, D; Millas-Vargas, JP; Retamal, E; Ramirez-Rodriguez, O; Pessoa-Mahana, H; Pavani, M; Ferreira, J; Cardenas, C; Araya-Maturana, R. FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/beta 1-integrin pathway. SCIENTIFIC REPORTS, 2018, 8, artículo número 13190.

    • Fuentes, M; Araya-Maturana, R; Palomo, I; Fuentes, E . Platelet mitochondrial dysfunction and mitochondria-targeted quinone-and hydroquinone-derivatives: Review on new strategy of antiplatelet activity. BIOCHEMICAL PHARMACOLOGY, 2018, 156, 215-222.

    • Urra, FA; Araya-Maturana, R . Targeting Metastasis with Snake Toxins: Molecular Mechanisms. TOXINS, 2017, 9, artículo número 390.

    • Martinez-Cifuentes, M; Cardona, W; Saitz, C; Weiss-Lopez, B; Araya-Maturana, R .  A Study about Regioisomeric Hydroquinones with Multiple Intramolecular Hydrogen Bonding. MOLECULES, 2017, 22, artículo número 593.

    • Martinez-Cifuentes, M; Salazar, R; Ramirez-Rodriguez, O; Weiss-Lopez, B; Araya-Maturana, R. Experimental and Theoretical Reduction Potentials of Some Biologically Active ortho-Carbonyl para-Quinones. MOLECULES, 2017, 22, artículo número 577.

    • Urra, FA., Córdova-Delgado, M., Lapier, M., Orellana-Manzano, A., Acevedo-Arévalo, L., Pessoa-Mahana, H., González-Vivanco, J.M., Martínez-Cifuentes, M., Ramírez-Rodríguez, O., Millas-Vargas, J.P., Weiss-López, B., Pavani, M., Ferreira, J., Araya-Maturana, R. Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation. Toxicology and Applied Pharmacology, 2016, 46-57.

    • Martínez-Cifuentes, M., Salazar, R., Escobar, C.A.,  Weiss-López, B.E., Santos, L.S., Araya-Maturana , R. Correlating experimental electrochemistry and theoretical calculations in 2′-hydroxy chalcones: the role of the intramolecular hydrogen bond. RSC Advances, 2015, 50929-50937.

    • Salazar, R., Vidal, J., Martínez-Cifuentes, M., Araya-Maturana, R., Ramírez-Rodríguez, O. Electrochemical characterization of hydroquinone derivatives with different substituent in acetonitrile. New Journal of Chemistry, 2015, 1237-1246.

    Link ResearchGate