MARIANO PERTINO
 
 

Perfil

  • Semi-sintesis de productos naturales

  • Relación estructura-actividad

  • Química de productos naturales
  • Formación Profesional

    Doctor en Ciencias (Universidad de Talca)

    Licenciado en Química (Universidad Nacional del Sur)

    Publicaciones Relevantes Últimos 5 Años

    • Cristina Theoduloz, Mariano Walter Pertino, Guillermo Schmeda-Hirschmann. 2014. Gastroprotective mechanisms of action of semisynthetic carnosic acid derivatives in human cells. Molecules, 19, 581-594.

    Mariano Walter Pertino, Valery Verdugo, Cristina Theoduloz, Guillermo Schmeda-Hirschmann. 2014. Synthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid. Molecules, 19, 2523-2535.

    Mariano Walter Pertino, Valery Verdugo, Cristina Theoduloz, Guillermo Schmeda-Hirschmann. 2014. Synthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid. Molecules, 19, 2523-2535.

    • Carlos Alberto Bueno, Flavia Mariana Michelini, Mariano Walter Pertino, Catalina Arredondo Gómez, Guillermo Schmeda-Hirschmann, Laura Edith Alché. 2015. Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway. Medical Microbiology and Immunology, 204, 575–584.

    Mariano Walter Pertino, Cristina Theoduloz, Estefania Butassi, Susana Zacchino, Guillermo Schmeda-Hirschmann. 2015. Synthesis, antiproliferative and antifungal activities of 1,2,3-triazole-substituted carnosic acid and carnosol derivatives. Molecules, 20, 8666-8686.

    • Crristina Theoduloz, Carla Delporte, Gabriela Valenzuela-Barra, Ximena Silva, Solange Cádiz, Fernanda Bustamante, Mariano Walter Pertino, Guillermo Schmeda-Hirschmann. 2015. Topical anti-inflammatory activity of new hybrid molecules of terpenes and synthetic drugs.  Molecules, 20, 11219-11235.

    Mariano Walter Pertino, Celeste Vega, Miriam Rolón, Cathia Coronel, Antonieta Rojas de Arias, Guillermo Schmeda-Hirschmann. 2017. Antiprotozoal activity of triazole derivatives of dehydroabietic acid and oleanolic acid. Molecules, 22, 369.

    Mariano Walter Pertino, Erina Petrera, Laura Edith Alché and Guillermo Schmeda-Hirschmann. 2018. Synthesis, Antiviral and Cytotoxic Activity of Novel Terpenyl Hybrid Molecules Prepared by Click Chemistry. Molecules, 23, 1343.

    • Cristina Theoduloz, Jans Alzate-Morales, Felipe Jiménez-Aspee, Maria Inés Isla, María Rosa Alberto, Mariano Walter Pertino, Guillermo Schmeda-Hirschmann. 2018. Inhibition of key enzymes in the inflammatory pathway by hybrid molecules of terpenes and synthetic drugs: In vitro and in silico studies. Chemical Biology & Drug Design, 1-10.

    • Alexander F. de la Torre, Akbar Ali, Bernhard Westermann, Guillermo Schmeda-Hirschmann, Mariano Walter Pertino. 2018.An efficient cyclization of lapachol to new benzo[h]chromene hybrid compounds: a stepwise vs. one-pot esterification-click (CuAAC) study New Journal of Chemistry, 42, 19591-19599.

    • Absolute configuration and 1H NMR characterization of Rosmaridiphenol Diacetate. Marcelo A. Muñoz, Nury Perez-Hernandez, Mariano W. Pertino, Guillermo Schmeda-Hirschmann, and Pedro Joseph-Nathan., Journal of Natural Products 75 (2012), 779−783.

    • Potential gastroprotective effect of novel cyperenoic acid - quinone derivatives in human cell cultures.Cristina Theoduloz, Ivanna Bravo Carrión, Mariano Walter Pertino, Daniela Valenzuela, Guillermo Schmeda-Hirschmann. (2012). Planta Medica, 78(17): 1807-1812.

    • Dimeric labdane diterpenes: synthesis and antiproliferative effects.Mariano Walter Pertino, Cristina Theoduloz, Marco Bastías, Guillermo Schmeda-Hirschmann. 2013. Molecules,18, 5936-5953.

    • 1,2,3-Triazole-substituted oleanolic acid derivatives: synthesis and antiproliferative activity.Mariano Walter Pertino, Cecilia Lopez, Cristina Theoduloz, Guillermo Schmeda-Hirschmann. (2013). Molecules, 18, 7661-7674.

    • Diterpenylquinone hybrids: synthesis and assessment of gastroprotective mechanisms of action in human cells. Cristina Theoduloz, Ivanna Bravo, Mariano Walter Pertino, Guillermo Schmeda-Hirschmann. (2013) Molecules, 18, 11044-11066.

    • Gastroprotective mechanisms of action of semisynthetic carnosic acid derivatives in human cells. Cristina Theoduloz, Mariano Walter Pertino, Guillermo Schmeda-Hirschmann. (2014). Molecules, 19, 581-594.

    • Synthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid., Mariano Walter Pertino, Valery Verdugo, Cristina Theoduloz, Guillermo Schmeda-Hirschmann. (2014).. Molecules, 19, 2523-2535.

    • Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway., Carlos Alberto Bueno, Flavia Mariana Michelini, Mariano Walter Pertino, Catalina Arredondo Gómez, Guillermo Schmeda-Hirschmann, Laura Edith Alché. (2015). Medical Microbiology and Immunology, 204, 575–584.

    • Synthesis, antiproliferative and antifungal activities of 1,2,3-triazole-substituted carnosic acid and carnosol derivatives. Mariano Walter Pertino, Cristina Theoduloz, Estefania Butassi, Susana Zacchino, Guillermo Schmeda-Hirschmann. (2015). Molecules, 20, 8666-8686.

    • Topical anti-inflammatory activity of new hybrid molecules of terpenes and synthetic drugs. Cristina Theoduloz, Carla Delporte, Gabriela Valenzuela-Barra, Ximena Silva, Solange Cádiz, Fernanda Bustamante, Mariano Walter Pertino, Guillermo Schmeda-Hirschmann. (2015). Molecules, 20, 11219-11235.

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