Guillermo Schmeda Hirschmann

Profesor Titular


Formación Profesional

BIOQUÍMICO, Universidad Nacional de Asunción, Paraguay (1978) (convalidado por la Universidad de Chile, 1990)

Título de la Tesis: Isolierung und Strukturaufklärung von Pflanzeninhaltsstoffen aus Compositae


  • 1987 The World Bank, Beca Robert S. McNamara
    "Natural Products as alternative in controlling Chagas' disease vectors".

  • Belo Horizonte, Brasil. 1996 Beca Alexander von Humboldt. Kaiserslautern, Alemania Federal.
  • Publicaciones

    • De la Torre, A.F., Ali, A.,  Westermann, B., Schmeda-Hirschmann, G.,  Pertino, M.W. (2019). An efficient cyclization of Lapachol to new benzo[h]chromene hybrid compounds: Tandem vs one-pot esterification-click (CuAAC) study. New Journal of Chemistry, Manuscript ID: NJ-ART-07-2018-003699.

    • Schmeda-Hirschmann, G., Burgos-Edwards, A., Theoduloz, C., Jiménez-Aspee, F.,  Vargas-Arana, G.  (2019). Male sexual enhancers from the Peruvian Amazon. Journal of Ethnopharmacology 229, 167-179 DOI 10.1016/j.jep.2018.10.007.

    • Schmeda-Hirschmann, G., Theoduloz, C. (2019).  Fabiana imbricata Ruiz et Pav. (Solanaceae), a review of an important Patagonian medicinal plant. Journal of Ethnopharmacology 228, 26-39.

    • Theoduloz, C., Alzate-Morales, J., Jiménez-Aspee, F., Isla, M.I., Alberto, M.R., Pertino, M.W., Schmeda-Hirschmann, G. (2018). Inhibition of key enzymes in the inflammatory pathway by hybrid molecules of terpenes and synthetic drugs: in vitro and in silico studies. Chem. Biol. Drug. Des. 2018;00:1-10 DOI: 10.1111/cbdd.13415.

    • Moreno, M.A., Gómez-Mascaraque, L.G., Arias, M., Zampini, I.C., Sayago, J.E., Pino R., L.L., Schmeda-Hirschmann, G., López-Rubio, A., Isla, M.I. Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations (2018). Carbohydrate Polymers 201, 425-437.

    • Jimenez Aspee, F.,  Theoduloz, C., Gómez-Alonso, S.,  Hermosín Gutierrez, I.,  Reyes, M.,  Schmeda-Hirschmann, G. (2018). Polyphenolic profile and antioxidant activity of the Chilean "chagual" (Puya chilensis Mol.), a salad from central Chile. Food Research International 114, 90-96.

    • Tallini, L.R., Bastida, J., Cortes, N., Osorio, E.H., Theoduloz, C., Schmeda-Hirschman, G. (2018). Cholinesterase inhibition activity, alkaloid profiling and molecular docking of Chilean Rhodophiala (Amaryllidaceae). Molecules 2018, 23, 1532; doi:10.3390/molecules23071532 (27 pp).

    • Jimenez-Aspee, F., Theoduloz, C., Burgos-Edwards; A., Schmeda-Hirschmann, G. (2018). Effect of polyphenols from wild Chilean currants (Ribes spp.) on the activity of intracellular antioxidant enzymes in human gastric AGS cells. Food Bioscience 24, 80-88.

    • Pertino, M.W., Petrera, E.,  Alché, L.E.,  Schmeda-Hirschmann, G. (2018). Synthesis, antiviral and cytotoxic activity of novel terpenyl hybrid molecules prepared by click chemistry. Molecules 2018, 23, 1343; doi:10.3390/molecules23061343, 12 pp.

    • Zolezzi, J.M., Lindsay, C.B., Serrano, F.G., Ureta, R.C., Theoduloz, C., Schmeda-Hirschmann, G., Inestrosa, N.C. (2018). Neuroprotective effects of ferruginol, jatrophone, and junicedric acid against amyloid-β injury in hippocampal neurons. Journal of Alzheimer´s Disease 63, 705-723 DOI: 10.3233/JAD-170701.

    • Burgos-Edwards, A., Jiménez-Aspee, F., Theoduloz, C., Schmeda-Hirschmann, G. (2018). Colonic fermentation of polyphenols from Chilean currants (Ribes spp.) and its effect on antioxidant activity and metabolic syndrome-associated enzymes. Food Chemistry 258, 144-155. DOI information: 10.1016/j.foodchem.2018.03.053.

    • Moreno, M.A.,  Córdoba, S., Zampini, I.C., Mercado, M.I., Ponessa, G., Sayago, J.E., Pino R., L.L.,  Schmeda-Hirschmann, G., Isla, M.I. (2018). Argentinean Larrea dry extracts with potential use in vaginal candidiasis. Natural Products Communications 13 (2), 171-174.

    • Moreno, M.A., Córdoba, S., Zampini, I.C., Alberto, M.R., Mercado, M.I., Nader-Macias, M.E.F., Sayago, J., Burgos-Edwards, A., Schmeda-Hirschmann, G., Isla, M.I. (2018). Tetraglochin andina Ciald.: a medicinal plant from the Argentinean highlands with potential use in vaginal candidiasis. Journal of Ethnopharmacology 216 283–294.

    • Ávila, F., Schmeda-Hirschmann, G., Silva, E. (2018). The major chromophore arising from glucose degradation and oxidative stress occurrence during lens proteins glycation induced by glucose. Molecules 23, 6; pp 1-13 doi:10.3390/molecules23010006.

    • Thomas-Valdés, S., Theoduloz, C., Jiménez-Aspee, F., Burgos-Edwards, A., Schmeda-Hirschmann, G. (2018). Changes in polyphenol composition and bioactivity of the native Chilean white strawberry (Fragaria chiloensis spp. chiloensis f. chiloensis) after in vitro gastrointestinal digestion. Food Research International  105, 10-18.

    • Jiménez-Aspee, F., Theoduloz, C., Soriano, M. del P. C., Ugalde-Arbizu, M., Alberto, M.R., Zampini, I.C., Isla, M.I., Simirgiotis, M.J., Schmeda-Hirschmann, G. (2017). The native fruit Geoffroea decorticans from the arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome associated enzymes. Molecules 22, 1565, 18 pp. PDF Version:
    Molecules 2017, 22, 1565; doi:10.3390/molecules22091565.

    • Strada, C.L., da Costa Lima, K., da Silva, V.C., Ribeiro, R.V., Dores, E.F.G de C., Dall'Oglio, E.L.,  Schmeda-Hirschmann, G., Carollo, C.A., Martins, D.T. de O., de Sousa Junior, P.T. (2017). Isovitexin as marker and bioactive compound in the antinociceptive activity of the Brazilian crude drug extracts of Echinodorus scaber and E. grandiflorus. Revista Brasileira de Farmacognosia   ISSN: 0102-695X   Elsevier Scielo.

    • Orqueda, M.E., Zampini, I.C., Torres, S., Alberto, M.R., Pino Ramos, L.L., Schmeda-Hirschmann, G., Isla, M.I. (2017). Chemical and functional characterization of skin, pulp and seed powder from the Argentine native fruit Mistol (Ziziphus mistol). Effects of phenolic fractions on key enzymes involved in metabolic syndrome and oxidative stress. Journal of Functional Foods 37, 531-540.

    • Burgos-Edwards, A., Jiménez-Aspee, F., Thomas-Valdés, S., Schmeda-Hirschmann, G., Theoduloz, C. (2017). Qualitative and quantitative changes in polyphenol composition and bioactivity of Ribes magellanicum and R. punctatum after in vitro gastrointestinal digestion. Food Chemistry 237, 1073-1082.

    • Torres Carro, R., Isla, M.I., Thomas-Valdes, S., Jiménez-Aspee, F., Schmeda-Hirschmann, G., Alberto, M.R. (2017). Inhibition of pro-inflammatory enzymes by medicinal plants from the Argentinean highlands (Puna). Journal of Ethnopharmacology 205, 57-68.

    • Pertino, M.W., Vega, C., Rolón, M., Coronel, C., Rojas de Arias, A., Schmeda-Hirschmann, G. (2017). Antiprotozoal activity of triazole derivatives of dehydroabietic acid and oleanolic acid. Molecules 22, 369; doi:10.3390/molecules22030369.

    • Ávila, F., Theoduloz, C., López-Alarcón, C., Dorta, E., Schmeda-Hirschmann, G. (2017). Cytoprotective effect mediated by polyphenols from Chilean native berries against free radical-induced damage on AGS cells. Oxidative Medicine and Cellular Longevity (Article ID 9808520, 13 pages)

    • Schmeda-Hirschmann, G., Burgos-Edwards, A., Rojas de Arias, A., Vega G., C., Alfonso, J., Rolon, M., Brusquetti, F., Netto, F., Urra, F.A., Cárdenas, C. (2017). The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells. Journal of Ethnopharmacology 199, 106-118.

    • Jiménez-Aspee, F., Theoduloz, C., Vieira, M.N., Rodriguez-Werner, M.A., Schmalfuss, E., Winterhalter, P., Schmeda-Hirschmann, G. (2016). Phenolics from the Patagonian currants Ribes spp.: isolation, characterization and cytoprotective effect in AGS cells. Journal of Functional Foods 26, 11-26.

    • Cattaneo, F., Costamagna M.S., Zampini I.C., Sayago, J., Alberto M.R., Chamorro V., Pazos A., Thomas-Valdés, S., Schmeda-Hirschmann, G., Isla, M.I. (2016). Flour from Prosopis alba cotyledons: a natural source of nutrient and bioactive phytochemicals. Food Chemistry 208, 89-96.

    • Nina, V., Quispe, C., Jimenez-Aspee, F., Theoduloz, C., Leiva, E., Feresin, G.E., Lima, B., Schmeda-Hirschmann, G. (2015). Antibacterial activity, antioxidant effect and chemical composition of propolis from Región del Maule, central Chile. Molecules 20, 18144-18167.

    • Pérez, M.J., Cuello, A.S., Zampini, I.C., Ordoñez, R.M., Alberto, M.R., Quispe, C., Schmeda-Hirschmann, G., Isla, M.I. (2014). Polyphenolic compounds and anthocyanin content of Prosopis nigra and Prosopis alba pods flour and their antioxidant and anti-inflammatory capacity. Food Research International 64, 762-771

    • Schmeda-Hirschmann, G., Quispe, C., Theoduloz, C., Teixeira de Sousa, P., Parizotto, C. (2014). Antiproliferative activity and new argininyl bufadienolide esters from the “Cururú” toad Rhinella (Bufo) schneideri. Journal of Ethnopharmacology 155, 1076-1085.

    • Simirgiotis, M.J., Bórquez, J., Schmeda-Hirschmann, G. (2013). Antioxidant capacity, polyphenolic content and tandem HPLC-DAD-ESI/MS profiling of phenolic compounds from the South American berries Luma apiculata and Luma chequén. Food Chemistry 139, 289-299.

    • Simirgiotis, M., Schmeda-Hirschmann, G., Borquez, J., Kennelly. E. (2013). The Passiflora tripartita (banana passion) fruit: a source of bioactive flavonoid C-glycosides isolated by HSCCC and characterized by HPLC–DAD–ESI/MS/MS. Molecules 18, 1672-1692.

    • Simirgiotis, M.J., Silva, M., Becerra, J., Schmeda-Hirschmann, G. (2012). Direct characterization of phenolic antioxidants in infusions from four medicinal Mapuche plants by liquid chromatography with diode array detection (HPLC-DAD) and electrospray ionization tandem mass spectrometry (HPLC-ESI-MS). Food Chemistry 131, 318-327.

    Link ResearchGate

    Editor Asociado

    Journal of Ethnopharmacology (Elsevier);

    Participación en Comités Editoriales:

    Evidence-Based Complementary and Alternative Medicine

    Chinese Herbal Medicines (CHM)

    Frontiers in Plant Metabolism and Chemodiversity

    Proyectos En Ejecución (En Chile)

  • FONDECYT 1120096. Metabolomics of Chilean native fruits (Investigador Responsable)

  • Listado de proyectos FONDECYT como Investigador Principal y Co-investigador:
  • Líneas de investigación

    Química y bioactividad de plantas alimenticias y medicinales sudamericanas. Perfiles de metabolitos bioactivos en matrices agroforestales. Alimentos tradicionales sudamericanos, nutracéuticos y recursos fitogenéticos nativos. Etnofarmacología y etnobotánica. Relaciones estructura-actividad en compuestos bioactivos. Mecanismos de acción de productos naturales/nutracéuticos empleando cultivos celulares.

    Por favor, ver en publicaciones: