Margarita Isabel Gutiérrez Cabrera		  
 

Licenciada en Biologia, Universidad de Talca

Doctor en Ciencias mencion Investigacion y Desarrollo de Productos Bioactivos

Laboratorio de Sintesis Organica y actividad Biologica: Sintesis, purificacion y caracterizacion espectroscopica de heterociclos nitrogenados y evaluacion de su actividad biologica.

Publicaciones Relevantes Últimos 5 Años

• Semisynthesis, Characterization and Evaluation ofNew Adenosine Derivatives asAntiproliferative Agents. Francisco Valdés Zurita, Nelson Brown Vega and Margarita Gutiérrez Cabrera. Molecules 2018, 23, 1111; doi:10.3390/molecules23051111.

• Design, facile synthesis, and evaluation of novel spiro and pyrazolo [1,5-c] quinazolines as cholinesterase inhibitors: Molecular docking and MM/GBSA studies.Jaime Gálvez, StivensPolo, Braulio Insuasty, Margarita Gutiérrez, Daniela Cáceres, JansH. Alzate-Morales, Pedro De-la-Torre, Jairo Quiroga. Computational Biology and Chemistry, 2018, 74, 218–229. https://doi.org/10.1016/j.compbiolchem.2018.03.001.

• Synthesis of novel 7-aryl and 7-spiropyrazolo[4_,3_:5,6]pyrido[2,3-d]pyrimidine derivatives and their study as AChE inhibitors. Paola Acosta, Braulio Insuasty, Rodrigo Abonia, Margarita Gutierrez, Jairo Quiroga. Mol Divers2017, 21:943–955. DOI 10.1007/s11030-017-9774-3.

• Microwave-assisted one-pot synthesis in water ofcarbonylpyrazolo[3,4-b]pyridine derivatives catalyzed by InCl3 and sonochemical assisted condensation with aldehydes to obtain new chalcone derivatives containing the pyrazolopyridinic moiety. Efrain Polo,  Karoll Ferrer-Pertuz, Jorge Trilleras,  Jairo Quiroga  and Margarita Gutierrez. RSC Adv., 2017, 7, 50044. DOI: 10.1039/c7ra10127a.

• N-{4-[(2E)-3-(2H-1,3-Benzodioxol-5-yl)prop-2- enoyl]phenyl}quinoline-3-carboxamide. Efrain Polo, Jorge Trillerasand Margarita Gutiérrez Cabrera. Molbank, 2017, M960; doi:10.3390/M960.

• Production of Secondary Metabolites by Immobilized Cells of Stereocaulon ramulosum (Sw) Rausch (lichen) in Different Design of Bioreactors Iris Pereira , Eugenia C Pereira and Margarita Gutiérrez. Journal of Chemical and Pharmaceutical Research, 2017, 9(5):104-109.

• Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation. Adriana V. Treuer, Pedro De-La-Torre, and Margarita I. Gutiérrez. Hindawi Journal of Chemistry, Volume,2017, Article ID 8418930, 8 pages https://doi.org/10.1155/2017/8418930.

• Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives. Efrain Polo, Jorge Trilleras, Juan Ramos, Antonio Galdámez, Jairo Quiroga and Margarita Gutiérrez. Molecules, 2016, 21, 903; doi:10.3390/molecules21070903.

• Novel N-allyl/propargyltetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels–Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors. Yeray A.Rodríguez, Margarita Gutiérrez, David Ramırez, JansAlzate-Morales, Cristian C. Bernal, Fausto M. Guiza and Arnold R. Romero Bohórquez. ChemBiolDrug Des2016; 88: 498–510.

• Chemicalcomposition and antibacterial activity of essential oils from Azorellaspinosa(apiaceae) against wild phytopathogenic bacteria .Adriana Jara-Bermeo, Patricio Peñailillo, Aurelio San-Martín, Omar Malagón,GianlucaGilardoni, Margarita Gutiérrez. J. Chil. Chem. Soc., 2016,61 (4).

• Exploring coumarin potentialities: development of new MAO-B inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold. Fernanda Borges, Eugenio Uriarte, Lourdes Santana, Andre Fonseca, María Joao Matos, Joana Reis, Margarita Gutiérrez, Yorley Duarte. RSC Advances . 2016.  DOI: 10.1039/C6RA05262B.

• Synthesis and insilicoanalysisofthequantitative structure activityrelationshipofheteroaryl–acrylonitrilesasAChEinhibitors. Pedro De la Torre, Adriana V. Treuer, Margarita Gutierrez, Horacio Poblete, Jans H. Alzate Morales, Jorge Trilleras, Luis Astudillo Saavedra, Julio Caballero. Journal of the Taiwan Institute of Chemical Engineers,2016. 59, 45–60. http://dx.doi.org/10.1016/j.jtice.2015.07.022.

• Monitoring and mechanisms of organophosphate resistance inSan Jose scale, Diaspidiotusperniciosus (Hemiptera:Diaspididae). K. A. Buzzetti, R. A. Chorbadjian, E. Fuentes-Contreras, M. Gutierrez, J. C. Rıos and R. Nauen. J. Appl. Entomol.2016, 140, 507–516. doi: 10.1111/jen.12283.

• Crystal structure of (E)-2-(benzo[d]thiazol-2-yl)-3- (pyridin-3-yl)acrylonitrile). Pedro De-La-Torre, Margarita Gutierrez, Julio Caballero, Jorge Trilleras, Luis Astudillo,Alejandro Cárdenas and Iván Brito. Z. Kristallogr. NCS 2016; 231(1): 171–173.

• DihydroagarofuranoidSesquiterpenes as Acetylcholinesterase Inhibitors from Celastraceae Plants: Maytenusdisticha and Euonymus japonicas.  Julio Alarcón,Carlos L. Cespedes,Evelyn Muñoz,Cristian Balbontin, Francisco Valdes, Margarita Gutierrez,Luis Astudillo,and David S. Seigler. J. Agric. Food Chem.2015, 63, 10250−10256. DOI: 10.1021/acs.jafc.5b04168.

• Tetrahydroquinolines and Isoxazoles: Nitrogen heterocycles as potential antibacterial agents. Yorley Duarte, Fernando Dueñas and Margarita Gutiérrez. Journal of Chemical and Pharmaceutical Research, 2015, 7(3):294-299.

• Docking's study of 6-substituted adenosine-5'-N-ethyluronamide analogs as selective agonists at A3 adenosine receptor and selection of compounds for to be synthesized later. Francisco Valdés, Z. Víctor Luna, Bárbara Arévalo, Margarita Gutierrez. Der Pharma Chemica, 2015, 7(6):212-225.

• Theantioxidant and antibacterialactivity of Azorellamultifidaonphytopathogenic bacteria. Jefferson Romero, Adriana Jara,Maria Elena Cazar, Aurelio San Martin and Margarita Gutierrez. Journal of Chemical and Pharmaceutical Research, 2015, 7(7):1194-1198.

• Nano-Detoxification of Organophosphate Agents by PAMAM Derivatives. Esteban F. Durán-Lara, Fabian Ávila-Salas, Sebastian Galaz, Amalraj John, Adolfo Maricán, Margarita Gutiérrez, Fabiane M. Nachtigall, Fernando D. Gonzalez-Nilo and Leonardo S. Santos. J. Braz. Chem. Soc., Vol. 26, No. 3, 580-591, 2015. http://dx.doi.org/10.5935/0103-5053.20150013.

• Molecular Docking Studies of the Antitumoral Activity and Characterization of New Chalcone. Aurelio San-Martin, Viviana Donoso, Sergio Leiva, Mitchell Bacho, Solange Nunez, Margarita Gutierrez, Juana Rovirosa, Natalia Bailon-Moscoso, Sandra Cuenca Camacho, Omar Malagon Aviles and Maria-Elena Cazar   Pages 1743 - 1749 (7). Current Topics in Medicinal Chemistry. 2015. DOI : 10.2174/1568026615666150427125033.

• Synthesis, molecular docking and design of Tetrahydroquinolines as acetylcholinesterase inhibitors. Margarita Gutiérrez, Bárbara Arévalo, Gonzalo Martínez, Francisco Valdés, Gabriel Vallejos, Unai Carmona and Aurelio San Martin. Journal of Chemical and Pharmaceutical Research, 2015, 7(3):351-358.

• Molecular Docking Studies of the Antitumoral Activity and Characterization of New Chalcone. Aurelio San-Martín, Viviana Donoso, Sergio Leiva, Mitchell Bacho, Solange Núñez, Margarita Gutierrez, Juana Rovirosa, Natalia Bailón-Moscoso, Sandra Cuenca Camacho, Omar Malagón Aviles and María-Elena Cazar. Current Topics in Medicinal Chemistry, 2015, 15, 1743-1749.

• Nano-Detoxification of Organophosphate Agents by PAMAM Derivatives Esteban F. Durán-Lara, Fabian Ávila-Salas, Sebastian Galaz, Amalraj John, Adolfo Maricán, Margarita Gutiérrez, Fabiane M. Nachtigall, Fernando D. Gonzalez-Nilo and Leonardo S. Santos. J. Braz. Chem. Soc., Vol. 00, No. 00, 1-12, 2015.

• Monitoring and mechanisms of organophosphate resistance in San Jose scale, Diaspidiotus perniciosus (Hemiptera: Diaspididae). K Buzzetti, R A Chorbadjian, E Fuentes-Contreras, M Gutiérrez, JC Ríos and R Nauen. Journal of Applied Entomology doi: 10.1111/jen.12283

• Dihydroagarofuranoid Sesquiterpenes as Acetylcholinesterase Inhibitor from Celastraceae Plants: Maytenus disticha and Euonymus japonicus.Julio Alarcon, Carlos L Cespedes, Evelyn Muñoz, Cristian Balbontin, Francisco Valdes, Margarita Gutierrez, Luis Astudillo, and David Seigler. J. Agric. Food Chem. 2015, 63, 10250−10256

• Antifungal and Insecticidal properties of the Phytoconstituents of Drimys winteri (Winteraceae) growing in Chiloe Island (Chile). Muñoz O, Gutierrez M, Gonzalez R, Hammann S and Vetter W. Nat Prod Chem Res 2015, 3:182. http://dx.doi.org/10.4172/2329-6836.1000182.

• Crystal structure of (E)-2-(Benzo[d]thiazol-2-yl)-3-(pyridin-3-yl) acrylonitrile). Pedro De-La-Torre, Margarita Gutierrez, Julio Caballero, Jorge Trilleras, Luis Astudillo, Alejandro Cardenas and Ivan Brito. Zeitschrift für Kristallographie - New Crystal Structures. Volume 231, Issue 1, Pages 171–173, ISSN (Online) 2197-4578, ISSN (Print) 1433-7266, DOI: 10.1515/ncrs-2015-0073, January 2016.

• Synthesis and in silico analysis of the quantitative structure activity relationship of heteroaryl–acrylonitriles as AChE inhibitors. Pedro De-la Torre, AdrianaV.Treuer, Margarita Gutierrez, Horacio Poblete, Jans H.Alzate-Morales, JorgeTrilleras, Luis Astudillo-Saavedra, Julio Caballero. Journal of the Taiwan Institute of Chemical Engineers 59 (2016) 45–60

• Exploring coumarin potentialities: development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold A. Fonseca, M. J. Matos, J. Reis, Y. Duarte, M. Gutierrez, L. Santana, E. Uriarte and F.Borges. RSC Adv., 2016, DOI: 10.1039/C6RA05262B.

• Novel N-allyl/propargyl tetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels–Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors. Yeray A. Rodrıguez, Margarita Gutierrez, David Ramırez, Jans Alzate-Morales, Cristian C. Bernal, Fausto M. Guiza and Arnold R. Romero Bohorquez. Chem Biol Drug Des. (Aceptado) 2016.

• Efficient MW-assisted synthesis, spectroscopic characterization, X-ray and antioxidant properties of pyrazole derivatives. Efrain Polo, Jorge Trilleras, Juan Ramos, Antonio Galdamez, Jairo Quiroga, Margarita Gutierrez. Molecules. doi:10.3390/molecules21070903