Nuestras lineas de investigación están asociadas al empleo de biomateriales para aplicaciones  en nanomedicina. Actualmente estamos enfocados en el desarrollo de cuatro  temas específicos.

El desarrollo de estas temáticas está caracterizado por un enfoque multidisciplinario empleando síntesis química tradicional  en conjunto con métodos químico-cuánticos y de simulación molecular, además de estudios  biológicos in vitro e in vivo.

Proyecto: FONDECYT Regular 1170426
Título: Novel PAMAM-Based Drug Nanocarriers with Potential Applications in Central Nervous System Diseases.
Rol: Investigador Responsable
Periodo: 2017- 2020

Proyecto: FONDECYT Regular 1160060
Título: Structure-based drug design of new tubulin binding agents with potential anticancer properties
Rol: Co-Investigador
Periodo: 2016-2019

Proyecto: Fondo institucional de fomento regional para el desarrollo científico, tecnológico y de innovación CONACYT-MEXICO.
Título: Impulso a la capacitación especializada, al desarrollo e innovación tecnológica en el área de fabricación de micro- y nano-dispositivos
Rol: Colaborador extranjero (Chile)
Periodo: 2016-2019

• Cytotoxicity and in vivo plasma kinetic behavior of surface-functionalized PAMAM dendrimers. Carola Diaz ; Carolina Benitez; Felipe Vidal; Luis F. Barraza; Veronica A. Jimenez; Leonardo Guzman; Jorge Fuentealba ; Gonzalo E. Yevenes; Joel B. Alderete, NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE 14, 2227-2234 (2018).

• Partially PEGylated PAMAM dendrimers as solubility enhancers of Silybin. Carola Diaz, C ; Jose Guzman; Veronica A. Jimenez ; Joel B. Alderete, PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 23, 689-696 (2018).

• Polyamido amine (PAMAM)-grafted magnetic nanotubes as emerging platforms for the delivery and sustained release of silibinin. Chavez, Gloria; Campos, Cristian H; Jimenez, Veronica A; Torres, Cecilia C ; Diaz, Carola; Salas, Gorka; Guzman, Leonardo; Alderete, Joel B. JOURNAL OF MATERIALS SCIENCE 52, 9269-9281 (2017).

• Association of Methotrexate with Native and PEGylated PAMAM-G4 Dendrimers: Effect of the PEGylation Degree on the Drug-Loading Capacity and Preferential Binding Sites. Luis F. Barraza ; Veronica A. Jimenez; Joel B. Alderete, JOURNAL OF PHYSICAL CHEMISTRY B 121, 4-12 (2017).

• Binding free energy calculations on E-selectin complexes with sLex oligosaccharide analogs. Pabla A. Barra; Antonio J.M. Ribeiro; Maria J. Ramos; Veronica A. Jimenez; Joel B. Alderete; Pedro A. Fernandes, CHEMICAL BIOLOGICAL & DRUG DESING 89, 114-123 (2017).

• PAMAM-Conjugated Alumina Nanotubes as Novel Noncytotoxic Nanocarriers with Enhanced Drug Loading and Releasing Performances. Cristian H. Campos; Carola F. Díaz; José L. Guzmán; Joel B. Alderete; Cecilia C. Torres; Verónica A. Jiménez, MACROMOLECULAR CHEMISTRY AND PHYSICS 217, 1712-1722 (2016).

• PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications. Cecilia C. Torres; Cristian H. Campos; Carola Diaz; Verónica A. Jiménez; Felipe Vidal; Leonardo Guzmán; Joel B. Alderete, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 65, 164-171 (2016).

• Discovery of New E-Selectin Inhibitors by Virtual Screening, Fluorescence Binding Assays, and STD NMR Experiments. Pabla A. Barra; Verónica A. Jiménez;  José A. Gavin; Antonio H. Daranas; Joel B. Alderete,  CHEMMEDCHEM 11, 1008-1014 (2016).

• Methotrexate Complexation with Native and PEGylated PAMAM-G4: Effect of the PEGylation Degree on the Drug Loading Capacity and Release Kinetics. Luis F. Barraza; Verónica A. Jiménez; Joel B. Alderete, MACROMOLECULAR CHEMISTRY AND PHYSICS   217,605-613 (2016).

• Effect of PEGylation on the Structure and Drug Loading Capacity of PAMAM-G4 Dendrimers: A Molecular Modeling Approach on the Complexation of 5-Fluorouracil with Native and PEGylated PAMAM-G4. Luis F. Barraza; Verónica A. Jiménez; Joel B. Alderete, MACROMOLECULAR CHEMISTRY AND PHYSICS 216, 1689-1701, (2015).